Oncothermia Journal Volume 10

“Abstract: This report introduces the overview and main mechanism of hyperthermia and summarizes the clinical application of hyperthermia in integrative natural therapies of cancer. According to the clinical experiences of the author, through statistical analysis, this report explains the orientation, application, and efficacy evaluation of hyperthermia in integrative natural therapies of cancer, as well as the understanding of the author. …”

“Introduction: Hyperthermia, applied regionally, is a potent sensitizer of radiation therapy in the treatment of cancerous tumors and as such has been used as a palliation measure or more recently with curative intent. The ability of Hyperthermia to reoxygenate tumor tissue makes hypoxic tumors, such as sarcomas or glioblastomas more responsive to radiation. In a prior publication we discussed good therapeutic results (over 80% 5 years survival) using Hyperfractionated Thermoradiotherapy (HTRT) in heatable superficial tumors.

“Introduction: Hyperthermia was one of the very first medical approaches. It was based on various religions and had deep philosophical roots in most of the ancient cultures. It was one of the popular “kitchen medicines” having various heating methods vivid in cultural wisdom of various societies. Probably this simplicity and natural character was one of the factors why the long history was not enough for its serious medical consideration despite the actually widely applied household techniques.

“Hyperthermia developed simultaneously in the late 1970s in academic centers and various CAM cancer clinics. Each developed along parallel tracks that addressed the needs of the various constituencies. Specific companies then arose to address the needs of each community. Today, interaction between the two “camps” is sporadic at best and sometimes even hostile. Before broader cooperation can occur each side needs to understand the particular conditions that give rise to their differing approaches. …”

“Aim: This presentation intends to expose the state of the art related to the clinical use of the combination of ozone and autologous plasma rich platelet (PRP) in different procedures which belong to the field of vascular medicine, traumatology and aesthetic medicine. …”

“With the increasingly advanced western psychology today, why should we still endeavor to study Chinese traditional medicinal psychology? That is because clinical psychology is a serving undertaking, whose effect depends on how much the psychological theories and methods stay in line with the consultative object's cultural background. Yet currently the clinical mental consultation in our country is basically copying and imitating the western psychological theories and methods.

“Today, we are not satisfied by achieving medical improvement, but curing the disease. However, traditional western medicine can not solve all of the medical problem, so it is important that we should find the solution to eliminate the “causes of disease”. “Self-defense capability diagnosis” is one of the method to find the causes of disease. In this paper, I am going to illustrate the mechanism and the theory of replacing electrons therapy, which will be popular in the medical field in the near future. “

“In vitro Vitamin C (Vit C) is known to kill cancer cells in a dose/concentration dependent way. In animals and patients high dose Vit C also is effective in cancer and higher dose/concentration is more effective. Protocols are used that get very high plasma concentration. There are many theories about why this works. One very popular theory is the pro-oxidant theory. Extracellular matrix (ECM) contains proteins which contain redox active metals like Cu or Fe. Vitamin C in the ECM reduces these protein bound metals (3+ → 2+).

“1. The current situation of thermal therapy and the basic assessment

“Abstract: Cancer is a disease with multiple interwoven causes and the role of diet has become a well-recognized factor in cancer incidence. It has also been described as “wounds that fail to heal”. Cancer is due to accumulation of DNA mutations that confer a growth advantage and invasive properties on clones of cells.

“Since hyperthermia has still not become an accepted treatment in oncology despite of 50 years of intensive research, the problems of hyperthermia method should be detected and analyzed.

“Abstract: It is the first effort aimed at the application of Music Therapy techniques to help in the prevention and treatment of depression in the older person in the Miraflores of Lima, Peru. The Biopsychosocial and Yesavage tests were applied to all patients.

“Abstract: The addition of hyperthermia to chemo radiation or radiation can enhance the efficacy and increase disease free and overall survival. The review is the documentation of single institution study to assess the effects of hyperthermia in conjunction with radiation alone and chemo-radiation. This data has been published earlier. The retrospective analysis of patients receiving either paclitaxel or cisplatinum along with radical radiation and weekly hyperthermia did yield spectacular survival in advanced head and neck cancer.

“Hyperthermia as anticancer treatment has been researched in the last decades and many mechanisms of action could be clarified. Investigations at the cellular level but also in animal experiments could show beneficial activity of the hyperthermia against cancer disease. Also in studies in human beings it could be shown that the activity of standard cancer treatments like radiation or chemotherapy could be enhanced by simultaneous hyperthermia. So in Germany the private health insurances cover the cost of hyperthermia in conjunction with chemotherapy and radiation.

“It is established that hyperthermic exposure is associated with the development of oxidative stress in cells [Finkel, Holbrook, 2000]. The oxidative stress in its essence is related to the process of massive release of free radicals. The possible mechanisms responsible for the development of this process has not been sufficiently examined, although some of them are known. For example, activation of the immune system in response to infection when for elimination of microorganisms, phagocytes begin "shoot" by Hydrogen Peroxide (HP) - a strong oxidant.

Abstract: In combination with low dose radiotherapy, superficial hyperthermia offers the possibility of achieving local control in previously irradiated recurrent breast cancers. Technically, this requires the ability to control temperature distribution in the heated tissue, to adapt heat application to changes in tumor volume, to avoid overheating of normal tissues and to minimize the risk of burns. Our clinical experience of combined hyperthermia-radiotherapy treatments using thermographic monitoring and control in chest wall recurrences is presented. …”

“Introduce: The use of the Booster in oncology can help to increase the action of both chemotherapy and other drugs. It can be used with all common cytostatics regardless whether these are administered orally, intravenously, rectally, inhaled or percutaneously. The Booster can be used for treating all types of cancer. The only limitation is the size of the electrodes. The treatment of metastases is also difficult. The Booster, which is the latest development from Oncotherm, was developed for oncology but can nevertheless also be successfully used in other medical fields.

“Purpose: To evaluate early clinical outcome of Oncothermia combined with concurrent radiotherapy (RT) and/or chemotherapy (CTx) in locally advanced non-small cell lung cancer (NSCLC). Materials and Methods: Since the introduction of Oncothermia (EHY-2000) machine at Yonsei Cancer Center in June 2012, a total of ten patients with locally advanced NSCLC were treated definitively with Oncothermia combined with concurrent RT and/or CTx-RT at Yonsei Cancer Center. …”

“Introduction: Hyperthermia was one of the very first medical approaches. It was based on various religions and had deep philosophical roots in most of the ancient cultures. The discovery of electromagnetism gave new hopes for oncological applications a century ago, however up to now it suffers from lack of wide acceptance. Medical challenges: The main problematic points of the extended applications are connected with the control of the process, the adequate dose and protocol of the method and the reproducibility of the results.

“Purpose: To evaluate the outcomes of percutaneous CT-guided radiofrequency ablation (RFA) for unresectable hepatocellular carcinoma pulmonary metastases (HCCPM) and to identify the prognostic factors for survival. Materials and methods: 320 patients with pathologically or clinically confirmed HCCPM between January 2005 and January 2012 were reviewed. 29 unresectable candidates (26 men and 3 women) with 58 HCCPM were treated with 51 percutaneous CT-guided RFA sessions. The outcomes, including safety, local efficacy, survival and prognostic factors were evaluated. …”

“Objectives of the work: Our paper has double objectives: first it is connected to the human medicine, aiming to model the natural human tumors much more realistically than the rodent tumor models. In this line we treat spontaneously occurring tumors and metastases on companion animals. During these experimental oncothermia treatments we can collect a huge amount of measured electromagnetic parameters that can help to understand what is really happening during oncothermia treatment and can help to optimize the next generation oncothermia devices.

“Objective: To explore the curative effect of Drug slow release depot therapy (DRSDT) for treatment of liver cancer. Methods: To conduct DRSDT on 288 cases of liver cancer patients. Results: According to WHO evaluation standard of curative effect for solid tumor, follow up and record the evaluation result, CE 5 cases, PR 151 cases, NC 125 cases, the total efficiency is 54,17% 3 year survival rate of stage II patients is 100%. And 1 year survival rate for stage III patients is 60.4%.

“Theoretical background: The hallmarks of cell death When is the cell dying? (=point-of-no-return) Massive caspase activation Mitochondrial transmembrane potential decreases (mitochondrial membrane permebilization) PS appears in the outer membrane of the cytoplasm. …”

“Objectives: To evaluate the feasibility, safety, and efficiency of percutaneous microwave ablation (MWA) with artificial pleural effusion for liver tumors located in the hepatic dome. Methods : 112 sessions of artificial pleural effusion performed on 102 liver tumor patients were summarized and analyzed in our hospital. Among them, 31 hepatocellular carcinoma (HCC) patients treated by percutaneous MWA were selected as artificial pleural effusion group.

“Aim: To explore the effect of junctional intercellular communication (GJIC) in hyperthermia-induced tumor invasiveness decreases process. Methods: Dynamic monitoring of HSP70 and Cx43 protein expression of C6 cells (western blotting and immunohistochemical methods); Study of GJIC on glioma by scrape-loading dye transfer method, detection of the glioma invasiveness with crystal violet staining method. …”

“Abstract: This paper gives a review on the indications, impact factors, contraindications, and research development of oncological hyperthermia. It also gives an introduction to the development, mechanism and method of the hyperthermia application in hot spring life cultivation. In addition, this paper also concludes that hot spring reaches the goal of life cultivation through a combination of physical effects (temperature, buoyancy, pressure) and chemical effects (microelements).

“Abstract: This paper presents a program on moxa-stick moxibustion therapy in large dose, which has a good effect in treating chronic lung disease.”

“Objective: To evaluate the clinical efficacy and safety of transcatheter arterial chemoembolization (TACE) combined with High-intensity Focused Ultrasound (HIFU) for primary hepatic carcinomas (PHC), and to provide the reference for clinical practice and research. Methods: We searched foreign databases as Cochrane Library, PubMed, EMBASE, Web of Science and Chinese ones as CBM, CNKI, VIP and Wanfang with computer and also retrieved other sources as supplying, such as tracing related references.

“Purpose: To discuss the prevention and treatment of common complications of tumor infrared WBH under medium or deep sedation. Method: Retrospective analyzed the treatment and prevention measures of complications during the WBH around hyperthermia treatment and after the hyperthermia for the 108 cases of patients with tumor. …”

“Abstract: Moxibustion is one of the external therapeutic methods in traditional Chinese medicine thermotherapy, and it plays an important role in dredging the channel, strengthening body resistance and eliminating evil, warming yang and correcting weakness, promoting qi to activate blood, and regulating yin and yang. The operation is simple, economic, safe and effective, and it has no toxic side effects and is easily accepted by patients, so it can give full play to its unique advantages in the prevention and treatment of diseases and health care.

“Objectives: To investigate the treatment efficacy of local hyperthermia in advanced lung cancer. Methods : 75 stage IIIb and IV lung cancer patients who were not a candidate for surgery, radiotherapy and chemotherapy were given local hyperthermia (mainly non-invasive radiofrequency and endogenous field hypothermia). 20 times for each course, 1 hour for per time, once every other day. Treatment efficacy, survival rate and life of quality were assessed before the treatment, after the treatment and every 6 months. …”

“Purpose: Sarcoma is a rare type of cancer. Surgery is known as the only treatment that shows definite response. But it represents high incidence of local recurrence and distant metastasis. Although it shows partial response to chemotherapy, there is no definitive chemotherapy regimen to control it effectively up to now. It is also known that sarcoma is resistant to radiotherapy due to having large portion of hypoxic cells.

“Fever-range whole-body hyperthermia (FRWBH) with an elevation of body temperature to 38.5-40.5°C is widely used in complementary oncology in Germany. Most of the clinics consider it as an important basic module of an integrative cancer therapy. But there are still a lot of questions on the mechanisms of FRWBH that are highly dependent from the therapeutic contexte. Commonly accepted is the immune-stimulating effect of FRWBH especially for the recovery of the immune system after immune-suppressive cytotoxic therapies.

“Abstract: Hyperthermia (HT) is a potent sensitizer for radiotherapy (RT) and chemotherapy (CT) and has been proven to modulate directly or indirectly cells of the innate and adaptive immune system. We will focus in this article on how anti-tumour immunity can be induced by HT. In contrast to some in vitro assays, in vivo examinations showed that natural killer cells and phagocytes like granulocytes are directly activated against the tumour by HT.

“Abstract: Hyperthermia (HT) - heating the tumor in the range of 40.0 - 44.0 0C - combined with radiation (RT) and/or chemotherapy (CT) is a well proven treatment for malignant tumors. The improvement of the techniques for monitoring and adapting of the desired temperatures even in deep seated tumors has led to a renaissance of, now quality-controlled, HT in multimodal tumor therapy approaches. Randomized clinical trials have shown improved disease-free survival and local tumor control without an increase in toxicity for the combined treatment.

“Purpose: Hyperthermia (HT) treatment of cancer patients was revived over the last years and has been proven to be beneficiary for many cancer entities when applied temperature controlled in multimodal treatments. We examined whether a combination of ionizing irradiation (X-ray) and HT (41.5 C; 1h) can induce the release of heat shock protein (HSP) 70 by tumor cells and thereby lead to the activation of dendritic cells and macrophages. …”

“Abstract: This paper summarize the influence of Moxibustion effects on Immune Function in patients diagnosed with cancer.”

“Objective: To explore the nursing care method in endogenous bladder treating with Hyperthermal Perfusion Chemotharpy. Method: Line method in bladder cancer peritoneal perfusion chemotherapy, chemotherapy drugs in the bladder give students field of hyperthermia. …”

“Objective: To investigate the treatment efficacy of deep hyperthermia for senile knee osteoarthritis. Methods: 60 cases of senile knee osteoarthritis patients were randomly divided into treatment group and control group. Treatment group: received radiofrequency deep hyperthermia treatment for 30 times. Control group: routinely received oral Non-Steroidal Anti-Inflammatory Drug -Ibuprofen capsules and Calcium Carbonate and Vitamin D3 for 30 days. Analgesic efficacy was observed, and joint function was evaluated. …”

“Purpose: To discuss the efficacies of extracorporeal RF deep hyperthermia in combination with traditional Chinese medicine treatment for haemorrheological and blood stasis type primary dysmenorrhea. Method: 130 cases of patients with dysmenorrhea have been divided into the treatment group and control group, 65 cases for each group. Treatment group: take traditional Chinese medicine Wenjing Soup orally plus extracorporeal RF deep hyperthermia; control group: only take traditional Chinese medicine Wenjing Soup orally. …”

“Purpose: To observe the biological electromagnetic pulse therapy for improving the quality of life of patients with cancer. Method: Apply biological electromagnetic pulse therapy on 108 cases of patients with cancer, one time per every 2 days, 10 times as one course of treatment. Conduct comparison before and after the treatment with the QOL rating sheet for patients with cancer. …”

“Purpose: In the present study, we investigated the potential of oncothermia (electro-hyperthermia) for an alternative therapeutic option of pan-human cancer. Materials and methods: To address this issue, we applied oncothermic heating (42oC 1 hour, three times with a two- or three-day interval) to various human cancer cell lines such as A549 (lung cancer), HepG2 (liver cancer), MDA-MB231 (breast cancer) and A172 & U-87MG (brain cancer), and then examined for cancer cell phenotypic changes. …”