Oncothermia Journal Volume 15

“Our objective is to show the weakness of the recent thermodynamics of chemical reactions. We show that such a thermodynamic theory of chemical reactions. which could be similar to the generalized Onsager's theory in thermodynamics. is not reality at the moment.”

“Hyperthermia enhances the susceptibility of tumors to radiotherapy (RT) and chemotherapy. Oncothermia, also known as electro-hyperthermia. is a new treatment modality developed to overcome the problems of traditional hyperthermia by selectively delivering energy to the malignant tissues. The present s1udy reports the outcome of combined oncothermia and RT in a 75-ycar-old patient with stage IIIB non-small-cell lung cancer ( SCLC).”

“Hyperthermia has been a modality to treat cancer for thousands of years. During this time, intensive efforts are concentrated on determining the dose of the proper treatment, but the dominantly in vitro induced cellular death does not provide enough confidence for the clinical dosing. The cell-death by heat·monotherapy applications in laboratory experiments is difficult to apply in the complementary therapies in clinical applications. The newly developed nanotechnologies offer completely new possibilities in this field as well.

Yuk-Wah Tsang, Cheng-Chung Huang, Kai-Lin Yang, Mau-shin Chi, Hsin-Chien Chiang, Yu-Shan Wang, Gabor Andocs, Andras Szasz, Wen-Tyng Li, Kwan-Hwa Chi (2015) Improving immunological tumor microenvironment using electro-hyperthermia followed by dendritic cell immunotherapy. Oncothermia Journal 15:55-66

“Our aim is to describe the physical and physiological effects of local modulated electro-hyperthermia (mEHT). The method concentrates on the energy absorption of cluster rafts of the plasma membrane. The targeted cluster contains transmembrane proteins, which can form coherent working voltage-gated ion channels and/or TRP receptors in one domain. This targeting is analogous to nanoparticle heating, except this uses readily available nanoparticles on the cell membrane instead of the artificially placed nano-object to induce selective energy absorption from the outside field.

Gabor Andocs, Mati Ur Rehman, Qing-Li Zhao, Edina Papp, Takashi Kondo,, Andras Szasz (2015) Nanoheating without Artificial Nanoparticles Part II. Experimental Support of the Nanoheating Concept of the Modulated Electro-Hyperthermia Method, Using U937 Cell Suspension Model. Oncothermia Journal15:77-86

“A theoretical study of the polymerization process of a cytoskeleton by an outside electric field is presented. We describe the reaction kinetics of polymerization of the cytoskeleton by Einstein"s approximation. The thermodynamic study of the equilibrium constant of the reaction kinetics shows the possibility of the reorganization of the cytoskeleton by the outside electric field. We show an effective stimulation of the polymerization which is connected to the effective value of the electric field and can certainly be modified by modulation of the carrier frequency.”

“Sarcomas are relatively rare malignancies; however, their huge variety and shortage of the effective therapies make this disease face huge challenge for oncology. It is recently shown that hyperthermia could be successfully applied even in high-risk cases in combination with the available gold-standard regiments. Our aim is to present various advanced cases treated with a new hyperthermia method, oncothermia, showing its advantages and feasibility to successfully treat highly advanced sarcomas with curative intent.”

“Purpose: Nefopam is a widely available analgesic for the management of pain. The aim of this study was to reveal Jhe effect of regional hyperthermia of the abdominal area on the pharmacokinelics of nefopam. Materials and methods: A randomised. single-dose. crossover. open-label study was conducted to reveal the effect of hyperthermia using modulated electro·hyperthermia on the pharmacokinetics of nefopam.”

“Lung cancer is one of the most aggressive and lethal form of cancers. Patients with far advanced lung cancer are treated by chemotherapy with or without radiotherapy. However, median survival of these patients is less than 6 months. To increase survival and quality of life for these patients, various forms of complementary treatments have been tried in clinical practices, and oncothermia is supposed to be one of the promising candidates.