Oncothermia Journal Volume 17

“The specific absorption rate (SAR) characterizes the energy intake from outside energy sources. Dominantly, the dosing of electromagnetic radiation uses the SAR, defining the absorbed power in unit mass, measured in W/kg. Ionisation radiation creates a certain distortion in the DNA, which is the goal of radiation in oncology. The dose in this case counts the time duration of the actual SAR, and uses the absorbed energy instead of the absorbed power, measured by Gy (=1/kg). The ionizing rate is the desired result, and the developed temperature is only an unwanted side effect.

“Dominant technical solution for oncological hyperthermia devices is capacitive-coupling. However, it has the challenge of overheating the surface of adipose layers and burning cutaneous structures. The main technical solution of this is the intensive cooling of the surface. Our objective is studying the physiology and effect of the active cooling of the skin in capacitive-coupled hyperthermia technologies.”

“Hyperthermia in oncology needs a definite dose which fixes well the clinical protocols. The temperature is far not a dose, it is mass independent. The half of the mass has the same temperature in equilibrium, so the basic criteria of the dose mass-dependence are lost. The energy could be a great option for dosing, (like it is in radiation therapies by Gy) but it has numerous drawbacks. These are discussed in this paper, trying to unify the dosing of ionizing and non-ionizing radiations.”

“We study a simple model of the capillary network of living systems. The volume flow of the blood versus pressure drop has a negative impedance interval, because the viscosity of the blood decreases with increasing shear rate. We explain the channel formation and deviations of the blood flow in solid tumours by this phenomenon.”

“The flow of blood is a non-Newtonian phenomenon, best described by Bingham fluids. We have given the basic balance equations and criteria. Due to the huge variation of the vessel diameters and consequently the complete flow behaviours of the blood in the actual vessel, we describe the similarities of flows.”

“We describe the Norwich-Wong generalization of the Weber-Fechner law in the framework of a complex, self-controlling, self-similar feedback mechanism to ensure the condition of “dendritic democracy”

“We describe the basic quantum-mechanical categories and properties of the thermodynamical basis of Onsager’s theorem. 3 basic principles are use: 1. Energy dissipation; 2. Hamiltonian formalism; 3. Onsager’s linearity. We obtain the 2 characteristic values of the observables, their main-value and the deviation, the first and second momentums of the probability distribution function, which we also derived also from the same principles.

“The effect of a modulated electromagnetic field on the cytoskeleton is possible through the action of voltage-sensitive phosphatase (VSP). Field-controlled phosphorous hydrolysis could have important roles in cytoskeleton restructuring, as well as in resonant-type behavior.”