Oncothermia Journal Volume 7

“Introduction Prostate cancer (Pca) is the most frequent cancer of men with approximately 31.500 new cases per year. The most important risk factor is age. Before age 50 clinically evident PCa are extremely rare and in most cases hereditary. More than 90% appears after age 60 and older. Between age 60 and 70 we expect that 50 of 100.000 men per year test positive for PCa and between age 75 and 85 approximately 400 men ….”

“Background Modulated electro-hyperthermia (mEHT) is a widely used non-invasive technique for targeted tumor treatment [1-4]. The capacitive coupled modulated radiofrequency enriches in the tumor tissue (because of its dielectric differences [5]) without harming the sorrunding non-malignant tissues. Beside the temperature dependent effect mEHT causes in the tumor tissue, it has a non-temperature dependent tumor destruction effect, which is three times higher than the conventional hyperthermia with the temperature dependent outcome only [6].

“Introduction Various kinds of hyperthermia devices are used in oncology, but the stable breakthrough of the applications has not been reached yet. Oncothermia offers strong scientific basis and good clinical practice as well. The very dynamic scientific and medical activity of Oncotherm is known in the scientific community through its many publications and accepted results. We are pioneering the electromagnetic treatments in oncology.

“Background

“Though oncothermia is becoming the world-leading hyperthermia technique, there is no clear, exact and unified rules of its clinical application. The approach stating oncothermia as an individualized treatment which is not possible to manage ‘in general’ makes oncothermia rather an art than a technology. Such an art is impossible to use widely in modern technological medicine. We developed a comprehensive but simple and clear ‘medical technology’ of oncothermia usage for Russian market named ‘Treatment of solid malignant tumors by oncothermia’.

“Surgery, radiation, and chemotherapy are main tumor therapy in veterinary field as well as human medicine. However, there are some cases which we cannot inhibit recurrence and metastasis, or control good QOL. In particular, almost tumors developed in the deep tissues like abdomen and thorax are recognized as poor prognosis. We applied Oncothermia against 10 tumors which developed in abdomen and thorax. Treatment was performed 3 times per a week and 6 times in total. At pre- and post-treatment, CT examination was performed and measured the size of tumor.

“With the development of clinical oncotherapies, integrative treatments have generally been recognized by the Oncology Association. Hyperthermia has proven its effectiveness in the treatment of cancer which is different from surgery, radiotherapy, chemotherapy and biotherapy. Besides integration with the above therapies, using this with TCM is a unique approach. The progress of research of hyperthermia integration with TCM in treating cancer will be presented according to the following six aspects:….”

“Abstract Hyperthermia was the very first first oncotherapy in human medicine based directly on sacral and philosophical roots in ancient cultures. The discovery of electromagnetism gave new hopes a century ago, however until up to now it has been suffering from lack of wide applications. Oncological hyperthermia struggles with multiple technical and medical problems which are far from the complete solution. Technically the deepheating, the precise focusing, the technical control and repeatability are challenging.

“The author directs an information and consultation service for people with cancer and their famiilies. To better inform his clients and readers, he travels around the world in search of new or innovative treatments that are clinically available for patients willing to travel. This travel has taken him to Asia, Latin America, most EU contries as well as most regions of the US. In this presentation, he will review his findings in various states and countreis, highlighting the use of complementary and alternative medicine (CAM) in various societis.

“Cancer accounts for 8 percent of death in India. Nearly 200,000 patients of new head and neck cancers are diagnosed in India. The overall survival of head and neck cancer has remained stable over 45-47% depending on race, socio-economic background and country. Organ sparing surgical techniques, and organ preserving approaches in the management of head and neck cancer are routinely practiced even in India. Hyperthermia despite being useful has not been a routinely available modality.

“The aim of this study was revealing the temperature changes in rats brain tissue caused by whole body hyperthermia. Analysis of received results allow to conclude, that the brain has a highly secured system of temperature autoregulation against the exogenous temperature changes. The upper limit of this autoregulation (for rats, at least) is in the range 45 oC of environment.

“Over the past decade, hyperthermia (HT) researchers have made cutting edge advances in HT augmented delivery of liposomal drugs. The performance characteristics of temperature sensitive liposomal formulations containing chemotherapeutic agents are far superior to other formulations largely because of the rapid release characteristic at temperatures between 40 and 42°C and a significant improvement in drug delivery. Several preclinical studies provided compelling rationale to initiate a number of clinical trials that will be presented.

“Introduction The prognosis for patients with advanced ovarian cancer remains bleak. 5-year survival in stage III is 5- 10%. Primary and acquired resistance of tumor cells to antineoplastic drugs is a major cause of the limited efficiency of chemotherapy. In our retrospective analysis we present the treatment results for patients with advanced ovarian cancer using whole body hyperthermia (WBH) in combination with a second line or palliative chemotherapy….”

“Benign and malign prostate hyperplasia and chronic prostatitis (CP) pose a constant challenge in urology due to the known limitations and risk of transurethral resection of the prostate gland and in the limitations of antibiotic therapy in CP. New treatment approaches therefore are warranted. The transurethral prostate hyperthermia has undergone enormous technological improvements in the last 20 years, particularly in the area of localized hyperthermia.

“Abstract Hyperthermia in oncology still remains an experimental treatment with no realistic future in clinical cancer therapy, though declaration of the undisputed efficacy of hyperthermia is a common place in every hyperthermia paper. We’ve studied available randomized trials on hyperthermia from the position of ‘null hypothesis’ to confirm or refuse the efficacy and safety of clinical hyperthermia, taking into account also the possible biases.

“The purpose of this study was to evaluate the activity and toxicity of electro-hyperthermia (ET) on relapsed malignant glioma patients. Twenty four patients with histologically diagnosed malignant glioma entered the study. Sixteen patients had glioblastoma multiforme, four had anaplastic astrocytoma grade III and four had anaplastic oligodendroglioma. All patients were pre-treated with temozolamide-based chemotherapy and radiotherapy. Hyperthermia with short radiofrequency waves of 13.56 MHz was applied using a capacitive coupling technique keeping the skin surface at 20 degrees C.

“Introduction It has been proven in malignant cancers, that in case of metastatic nodes in the head and neck region [1, 2, 3, 4, 5, 6] and in several other locations [8, 9, 10] hyperthermia potentiates radiation therapy. Due to these early findings, clinical applications were limited to recurrent advanced or metastatic cancers [11, 12, 13].

“Abstract In the recent years many new cancer clinics are using hyperthermia for the treatment of cancer We treat patients by an empirical way: One hour each session, Every other day one month, two months, more? Alone or combining with other treatment methods. What are the best ways to use the hyperthermia?...”

“It is accepted that the increase in core body temperature above 41.5 ° C may help to destroy tumor cells. Life of cancer patients is particularly threatened by the metastasis. Therefore systemic treatments are preferred. The discussion of the last two decades showed that every tenth of temperature increase helps to improve the damage of cancer cell. Studies by Suvernev et al confirmed efficient reduction of viruses infected individuals at temperatures above 42.5° C.

“Abstract We describe results in unresectable pancreatic tumors treated with USgHIFU hyperthermia ablation plus adjuvant chemotherapy. Materials and Methods: 32 cases of non resectable pancreatic tumors were treated from March 2010 to March 2012, and all of them underwent systemic chemotherapy. Clinical responses (thermical ablation achieved) were measured by image techniques. They were 23 Stage III cases and 9 Stage IV cases. Complications were also analyzed….”

“Today the adenocarcinoma of the pancreas shows a significant increase of incidence, mainly in western countries. This tumor tends to affect mainly the male population, smokers and has a marked effect in proportion to the increase of age. Recent studies have shown a correlation between pancreatic cancer and diets high in animal fat and protein, and the role of coffee is discussed.

“Abstract Hyperthermia has long been known to interfere with the tumor metabolism. The goal of this presentation is to review the potential of metabolic therapy and to suggest that its combination with hyperthermia may be of interest.

“Keywords Hypoxia, innate immunity, immune-suppression, glycolysis, tumor metabolism, hyperthermia.Introduction The local inflammatory reaction is characterized by an initial increase in blood flow to the site of injury, by increased vascular permeability and by an ordered influx of different effector cells, recruited from the peripheral blood and bone marrow to the site of lesion (1) Another characteristic of the inflammatory reaction is the presence of hypoxia and its modulation of innate immunity (2)….”

“Abstract Application of electric current for the tumor-destruction has a long time history. The theory of the direct galvanic current (galvano-therapy, GT) is worked out by B.Nordenstrom in the frame of biologically closed electric circuits (BCEC). Later GT was extended by chemical considerations (EChT) and starting with pioneering work of Professor Xin YouLing, a wide, intensive application had been developed in China. My objective is showing the principles and practice of the EChT treatment modality for multiple advanced lesions….”

“Absract For at least 2,500 years, acupuncture has been an integral part of traditional Chinese Medicine. Recently more people have been diagnosed with chronic disease and many of them have been poorly treated with conventional therapies. Those patients frequently prefer other forms of complementary medical treatments. Based on the theory of homeostatic equilibrium being the basis of health, acupuncture focuses on restoring the homeostasis by manipulating the complementary and opposing elements of yin and yang.

“Abstract Objective: To analyze the effect of Deep Regional Hyperthermia in combination with Traditional Chinese Medicine (TCM) in treating benign diseases in Clifford Hospital. Methods: We had 143 cases with chronic pelvic inflammatory disease, 36 cases with chronic prostatitis, 21 cases with prostatic hyperplasia, and 35 cases with chronic bronchitis, and we performed the treatments as planned. The following treatments were given: Radiofrequency (RF) hyperthermia, TCM, Acupuncture, Antibiotic therapy….”

“Abstract Gastric Cancer (GC) is one of the most critical diseases around the world. Population of its morbidity reaches 1,000,000 every year, among which 42% patients are in China. Thus, both the incidence and the mortality of GC are twice as much as the average level in the world. Clinical practitioners and basic researchers have been working on it for years, trying to find effective and long-acting therapeutic method focusing on GC. Till nowadays, no one can deny that radio-chemotherapy and operation have nonnegligible side effects.

“Objective The abscopal effect on the tumor is a distant antitumor activity induced by local treatments. The study was to observe the induction of abscopal effect by the combination of dendritic cell therapy with oncothermia therapy.Methods SCCVII (mouse squamous cell carcinoma) cells were injected into C3H/He mice at two separate sites, defined as a “primary” site that was treated and a “secondary” site outside the field of treatments…”

“Whole body hyperthermia plays an important role in the concept of biological cancer therapy, mostly in palliative situations. In the adjuvant setting, there has only been casuistic data until now. The talk shows the immunology during / after chemotherapy and provides an overview of the immunological significance of fever, which most cancer patients have not experienced for many years before the disease. Since the opening of the praxis in early 2002, a collective of now > 60 patients (mainly breast cancer) has been observed.

“Summary This is the first case report using different viruses to attack one tumour. They were chosen by the very unique method of human medicine: The patient, i.e. the highest authority, was asked to observe the development of the most conspicuous tumour associated symptoms in the course of therapy. The tumour was located in the gyrus cinguli on the right side of the frontal lobe, depressing the right ventricle and causing weakness of the left arm and leg. At the beginning of treatment the degree of these symptoms was estimated as 100%.

“Abstract Lyme-Disease is a tick-borne disease with multiple organ failure and systemic disorder. Dramatic change becomes apparent in the chronic phase of the disease. Chronic fatigue syndrome, lapse of concentration, depression, joint pain, muscle pain are a few, but major clinical symptoms characterizing the disease. The human immune-system is defenseless. Borrelia uses various mechanisms to escape from immuno-attacks or antibiotic therapies. This „stealth phenomenon“ needs new therapeutic principles to be interrupted.

“Peyronie’s disease is characterized by a scarring fribrosis within the tunica albugina of the penis that could lead to penile length loss, narrowing, curvature, erectile dysfunction, pain with erection.

“‘Hyperthermia is generally regarded as an experimental treatment with no realistic future in clinical cancer therapy’ – Horsman and Overgaard said in 2007, though, trying to combat this statement. It’s difficult to find another method in medicine which remains experimental after 40 years of research and application. Hyperthermic community usually claims to technical problems of heating and heating control to justify this failure. To our mind, the problem is the ‘temperature concept’ of hyperthermia.

“Abstract Oncothermia is a method of hyperthermia in oncology, controlling the locally applied deep-heat by selectively targeting the cellular membrane of the malignant cells. The selection of the method is based on various biophysical and biochemical achievements. There are various differences between the malignant and healthy cells, which could be used for their selection by heat targeting. The primary selection factor is a different metabolic activity which creates distinguishable environments of the malignant cells.

“Abstract There are many contradictory opinions about conventional hyperthermia in oncology. The main points are the physical, technical imperfection of classical heating, as well as the limits of the natural physiological feedback of the organism. We would like to present the definitive differences between oncothermia conventional hyperthermia, explaining the new line of problem-solving in this important field of oncology. Keywords: hyperthermia, oncothermia, nanotheremia, non-equilibrium, modulation….”

Abstract Oncothermia was introduced to our hospital in 2010. Our objective is to report results of 277 patients treated by oncothermia during 20 months. We present some characteristic cases and statistical study of the overall results. We concluded state the feasibility of oncothermia to treat high variety of malignant diseases also in their very advanced (T4N3M1) stages….”  

“Abstract There is a long history of hyperthermia in oncology, but its wide range acceptance and application is missing even today. A new approach of oncological hyperthermia, oncothermia, looks promising modality of the complementary treatment of advanced malignant cases. Our present article is targeting this method, trying to answer on the question of its feasibility to treat various advanced cases in monotherapy process, as well as its applicability for a long, large number of treatment sessions protocols….”

“Abstract Radiotherapy has a relevant action on the tumor environment and its distant component. Abscopal effect is the bystander effect of radiotherapy observed at a site distant to the irradiated one within the same patient. Abscoopal effect even though described, is not a common clinical event. We are reporting a documented observation of an abscopal effect in one patient with lung cancer treated on target with radiotherapy and oncotehrmia.

Kovago Cs, Meggyeshazi N, Andocs G, Szasz A (2013) Report of the pilot-study done for the proposed investigation on the possible synergic effect between high dose ascorbic acid application and oncothermia treatment. Oncothermia Journal 7:283-284

“Abstract Background: Modulated electro-hyperthermia (mEHT) is a non-invasive technique for targeted tumor treatment. Method: HT29 human colorectal carcinoma cell line xenografted to both femoral regions of BalbC/nu/nu mice treated with a single shot OTM treatment. Histomorphologic, and immunhistochemical analysis TUNEL assay and R&D Apoptosis array were performed on tissue samples…”

“Abstract This single arm, retrospective, single institution study investigated intention to treat patients (n=72) with advanced cancer of cervix of uterus. The study was performed in 2001-2010; providing 331 sessions. All patients had radiotherapies as fractional radiotherapy and intracavital brachytherapy. Some patients (n=34) received chemotherapy (Cisplatin 40 mg/m2/week; concomitantly with teleradiotherapy) as well. Complementary to the tele-radiotherapy, oncothermia was used two times a week, targeting the pelvis. Applied energy dose was 45 W, 60 min…”

“Abstract Approximately 800 metastatic liver cases were treated with oncothermia in our department. Many of them had long-time, cumulatively, huge number of treatments handled the disease a chronic for years. We investigated the long-time effects of the treatments, together with them interruption of the treatment serial for a few weeks. We are reporting a typical case: mammary carcinoma with liver metastases. The metastatic lesion was treated for four years, but the termination of the treatment for two months was fatal at the end….”

“Background

“Introduction Worldwide, breast cancer accounts for 22.9% of all cancers (excluding non-melanoma skin cancer) in women and it is more than 100 times more common in women than in men, although men tend to have poorer outcomes due to delays in diagnosis. Prognosis and survival rates for breast cancer vary greatly depending on the cancer type, stage, treatment and geographical location of the patient. Survival rates in the western world are high, in developing countries, however they are much poorer….”

“Abstract

“Abstract Oncothermia is a nanoheating technology personalized for individual status depending on the state, stage, grade, and other personal factors. The guiding line of the treatment keeps the homeostatic control as much effective as possible. One of the crucial points is the surface heat-regulation, which has to be carefully done by the electrode systems. The applied step-up heating supports the physiological selection. Recognizing the hysteresis type of SAR-temperature development the protocol could be well conducted….”

“Abstract Temperature in depth of in various model-systems was measured, starting with muscle and other phantoms. Temperature was measured by flouroptical system (Luxtron) in the various points of the phantoms. It was shown that the temperature can be selectively increased in the target. In water-protein phantom the protein coagulation (>60 °C) was observed selectively while the water temperature around it was a little higher than the room temperature….”

“Abstract Conventional hyperthermia is based on the local or systemic heating, which is measured by the realized temperature in the process. Oncothermia applies nano-heating, which means high energy absorption in nanoscopic range of the malignant cell-membrane selectively. This high temperature and its consequent stress create special effects: it evolves possibility of chaperone proteins to be expressed on the outer membrane by softening the membrane, and starts various excitations for programmed cell-death of the targeted malignant cell….”

“TCM and cancer

“Method: I would like to introduce the organizational structure and processes of Oncotherm Group and the requirements which should be adapted (see above). The Oncotherm Group consists of two parts: the Oncotherm Kft., which is in Hungary and the Oncotherm GmbH, which is in Germany, but these two firms are one unity. They are working together and they have got common quality management systems….”

“Abstract Medical devices are complex products requesting high level of safety and reliability because of their sophisticated functions. Automation of the quality control and the visualization of the steps of the production processes are useful supports of the production process. Our objective is to show a way of production support by LabView system….”

“Absract

“Background

“Abstract Small cell lung cancer constitutes approximately 13% of all lung cancer types & SCLC is one of the most aggressive and lethal forms of lung cancer. And so chemotherapy including radiotherapy would be standard for SCLC, but it has very poor median survival of less than 4 months. This is why another form

Posters Fiorentini G, Milandri C, Dentico P, Giordani P, Catalano V, Burnkeila F (2013) Deep electro-hyperthermia with radiofrequencies combined with thermo-active drugs in patients with liver metastases from colorectal cancer (CRC): A phase II clinical study. Oncothermia Journal 7:35-358 “Purpose increase palliation  in patients with liver metastases from CRC evaluate capacitavely coupled low-frequency 13.56 MHz deep hyperthermia cmbined with thermo-active drugs …”

“Rationale for using liposomal doxorubicin Temozolomide is an imido-tetrazine readily absorbed orally and able to cross the blood brain barrier. TMZ has demonstrated activity against Glioblastoma and astrocytoma n various degrees, and in brain metastases (Reardon DA 2006, Addeo R 2011)….”

“Introduction

“Background Modulated electro-hyperthermia (mEHT) is a non-invasive technique for targeted tumor treatment. The mEHT generated capacitive coupled modulated radiofrequency selectively accumulates in the tumor tissue without major effect in the surrounding normal tissues….”

“Among malignant gynecologic diseases the morbidity of the squamous cell, planocellular carcinoma of uterine-cervix is 1300-1400 cases yearly, with mortality of 500 cases yearly in Hungary [approx. 10 million inhabitants]….”

“Introduction

“Background

“Introduction In our long experience in Universitary Hyperthermia treatment of tumors associated with chemotherapy, we observed that response to associated treatment determines the disease stabilization and significant clinical benefit for 24 months in 12 cases of metastatic breast cancer,  whereas chemotherapy alone had shown ineffective with disease progression, bone marrow toxicity G3-4, fatigue G2-3, nausea and vomiting G1-G2, bone pain G3-4 and visceral pain G2-3. (Table 1)….”

“Introduction Hyperthermia in oncology had been extensively studied since 60th. Despite of more than 13.000 publications, 50 monographs and manuals and more than 1200 clinical trials, hyperthermia is still not accepted as a regular cancer treatment. The current trial was performed for further eexplanation of this situation….”

“Introduction The investigation of technologies which can increase cancer treatment efficacy is driven by: The high prevalence of Human Immunodeficiency Virus (HIV) and cervical cancer in South Africa1,2 The growing concerns that HIV infection and certain Antiretroviral Therapies (ARTs) increase the sensitivity to radiation therapy (RT) and chemotherapy,3,4,5 The economic impact of cancer on the already over-burdened healthcare system and economy in Afric6….”

“Background

“Objective The personalization of the oncological treatments is the new trend in modern medicine [1]. Oncothermia is a personalized treatment by tuned energy delivery to the targeted tumor [2].  This energy is well focused on cellular level [3], and makes the dose of energy optimal for cell destruction [4]. The personal feedback of the patient together with the natural homeostatic control of the treatment actions makes the treatment realistically personalized [5]…”

“Introduction The controlled and focused heat-delivery to deep-seated tissues is a long-standing problem of the local hyperthermia in oncology, [1]. The multiple artificial methods to focus the temperature has numerous technical and physiological problems. The energy could be focused in planned accurate way, but the temperature is naturally spread, as well as the physiological controls likely contra-effects the actual heating process. Our objective is to show how oncothermia makes the energy delivery in controlled way in depth….”

“Objective Oncothermia is a new type of cancer treatment targeting the malignant cells on nano-range, at its membrane and exciting basic cellular signaling pathways, [1].  The front-line achievements enplaning the cellular differences between malignant and healthy cells were not used for selection in practical applications. Our objective is to show how oncothermia uses these brilliant and strongly proven results….”

“Objective One of the most special and distinguished effect of oncothermia is the modulation. This special effect is important for selection and apoptotic action of oncothermia, applied on basic of multiple patents, [1], [2], [3]. The applied amplitude modulated signal is of course not simple. Presently the amplitude modulated electromagnetic applications have their renewing in the professional literature [Szasz et al Oncothermia, Springer, 2010]. Our objective is to show the oncothermia modulation which is a new way of the modulation technique….”

“Introduction – Objective

“OncoTherm Group Common Quality Management System based on: ISO 9001:2008 Quality Management System, Requirements ISO 13485:20003/AC:2009 Medical Devices Quality Management Systems. Requirements for regulatory purposes 93/42 EEC Medical Device Directive (MDD)…”

“What are the limits of the old hyperthermia approach? New paradigm is necessary for oncology Hyperthermia contradiction: “The biology is with us while the physics is against us” (J. Overgard) Oncothermia changes the paradigm: “The biophysics is with us”…”

“The necessity of integrated data-acquisition systems During the production of a product a lot of tests and measurements are done. First the electronic boards are checked separately, then the modulates which are built from them are tested separately, and finally a lot of tests are conducted on the assembled system. During these test a lot of data is acquired from the product, but – especially at the final testing of the product – the data acquisition could be difficult, because …”

“Abstract Hyperthermia means overheating of the living object completely or partly. Hyperthermia the procedure of raising the temperature of a parts of or the whole body above normal for a defined period of time, is applied alone or as an adjunctive with various established cancer treatment modalities such as radiotherapy and chemotherapy….”

“Introduction Oncothermia (OTM) is an electro-hyperthermia modality, a long time (since 1989) applied method in oncology [1] with great clinical success [2]. OTM changes the paradigm of hyperthermia by targeted microscopic heat liberation at the membrane of the malignant cells. This method creates inhomogeneous heating, microscopic temperature differences far from thermal equilibrium. The tumor destruction efficacy and the role of temperature independent effects of the OTM was proven earlier by laboratory research, and presented elsewhere [3], [4]….”

“Abstract Modulated electro-hyperthermia is an emerging complementary treatment option for refractory solid tumor. Early experience suggests that it may have advantages over conventional hyperthermia with exceeding efficacy, and less complication. Herein, we describe a case of platinum-resistant, refractory ovarian cancer successfully controlled by the combination of electro-hyperthermia and dose-dense chemotherapy…”

“Introduction Small cell lung cancer (SCLC) has more rapid doubling time and earlier development of widespread metastasis than non-small cell lung cancer. SCLC is highly sensitive to initial chemotherapy (CTx) and radiotherapy (RTx) but, recurs or spreads quickly. In addition, the surgical role in SCLC is still insignificant. So, the new treatment modality besides conventional treatments is needed to get a better prognosis. The aim of this study is to evaluate the effectiveness of hyperthermia in SCLC patients. …”

“1. Central nervous system tumors 3 Man with gliomas an 1 man with astrocytoma. We noticed general improvement as regarding to their performance status and reduction of their tumor mass in routine radiologic tests. 2. Head and neck-oral cavity 1 Man suffering of tongue cancer who received 12 trials of local deep-heat (HT) treatment having received chemo-radiotherapy before. This men developed progressive, disease with lung metastases in the end of the treatment…”

“Sales organization Organization and coordination/support: Oncotherm GmbH, Germany Freelancer in Germany: The Pockwood Corporation …”

“Main products Booster This product is new kind of innovations in the field of complementary cancer treatment. Its use enhances the effects chemo- and/or radiotherapies, as well as applicable for drug-targeting and personalization of any other medications, irrespective its i. v, oral, injection or other introduction. …”

“Summary of oncothermia application Applicator Applicator size should match the application gene and tumor size….”

“World Federation of Chinese Medicine Societies (WFCMS) is an international academic organization voluntarily formed by group members in the world of Traditional Chinese and Natural Medicine. Currently, WFCMS has 220 society members in 58 countries and regions….”

“Dear Collegues, Dear Members of ICHS, Dear Oncotherm-users, Hyperthermia started to be an integrative part of the onco-therapies. Ours Society is one of the oldest in this field. ICHS from its establishing  represented the best traditions of the oncological hyperthermia, uniting the best national and international efforts to accept widely this complementary treatment….”

“    -     Cancer Coaching Cancer Prevention Conventional Chemotherapy Metronomic Therapy Insulin Potentiation Therapy Hyperthermia …”

“Backgrounds Lung cancer is the leading cause of cancer death worldwide. With combination chemotherapy, the median survival is 8-10 months. Besides chemotherapy, various modalities have been evaluated to get better survival. Hyperthermia is a new therapeutic approach and has synergistic effect with chemotherapy to control the disease and to improve the survival….”