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The modulation is far from any sinus or other periodic patterns; it is a 1/f spectrum having definite templates for its construction. In some personalized cases, a definite template is used for the fractal pattern, which is copied from the actual character of the tumor pathology or any other specialty of the target. Oncothermia modulation is one of the three specialties of the Oncothermia treatment. Its efficacy and its role in the personalization process have introduced an effective tool for the apoptotic cancer cell destruction. The modulation makes a definitely and significantly higher tumor destruction compared to the nontreated side.