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10/18/2018 - 12:08 | Clinical External News

New publication about a suggestion of treatment of malignant brain tumors using Nanothermia or modulated-electro-hyperthermia (MEHT)

Nanoparticles and nanothermia for malignant brain tumors, a suggestion of treat…
Brain Tumor
Brain Tumor

Glioblastoma, also known as glioblastoma multiforme (GBM), is the most aggressive cancer that begins within the brain. Initially, signs and symptoms of glioblastoma are non-specific. They may include headaches, personality changes, nausea, and symptoms similar to those of a stroke. Worsening of symptoms often is rapid. This may progress to unconsciousness. (https://en.wikipedia.org/wiki/Glioblastoma)

 

It is our pleasure to share a new publication about a possible treatment of brain tumors, such as glioblastoma multiforme (GBM)

Title of the publication:

Nanoparticles and nanothermia for malignant brain tumors, a suggestion of treatment for further investigations

Authors:

Prieto C, Linares I

Abstract

The current treatment for brain tumors, such as glioblastoma multiforme (GBM), has not been developed enough yet in order to fully heal them. The main causes are the lack of specificity of the treatments, the difficulty of passage of drugs through the blood–brain barrier, heterogeneity and tumor aggressiveness, and widespread dissemination in the brain. The application of nanoparticles (Nps) have been a breakthrough for both diagnostic imaging and targeted therapies. There have been numerous studies with different types of Nps in brain tumors, but we have focused on thermosensitive liposomes, which are characterized by releasing the chemotherapeutic agent included within its lipophilic membranes through heat. Furthermore, increasing the temperature in brain tumors through hyperthermia has been proven therapeutically beneficial. Nanothermia or modulated-electro-hyperthermia (MEHT) is an improved technique that allows to create hot spots in nanorange at the membrane rafts, specifically in tumor cells, theoretically increasing the selectivity of the damage. In scientific records, experiments that combine both techniques (thermosensitive liposomes and nanothermia) have never been conducted. We propose a hypothesis for further research.

 

For the publication please see here: https://www.ncbi.nlm.nih.gov/pubmed/30263017