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Latest publications – ICHS and Research

As cancer treatment is always advancing, we believe that the approach of Oncothermia, mEHT could be a potential to change the aspects of how we treat cancer. With these recently published outstanding research and presentations, we aim to provide our readers with an understanding of Oncothermia’s role in modern oncology, shedding light on its transformative impact on cancer treatment paradigms.

Find these presentations of the latest ESHO-ICHS event below:

Minnaar,C.A.;Kotzen,J.A.:
Modulated electro-hyperthermia added to chemoradiotherapy improves five-year survival: final results of a phase III randomised controlled trial,

35th Annual Meeting of European Society for Hyperthermic Oncology, 2023.09.26-28.

Van Gool, S.W., Van de Vliet, P., Kampers, L., Kosmal, J., Sprenger, T., Schirrmacher, V., Stücker, W.:
Multiphase combined treatment for adults with GBM, including individualized multimodal immunotherapy: Single institute real world medical data in the light of clinical trial research data,

35th Annual Meeting of European Society for Hyperthermic Oncology, 2023.09.26-28.

Fiorentini Giammaria:
Palliative treatment containing modulated electro-hyperthermia alone or combined with chemotherapy versus second or third line of chemotherapy in patients with advanced pancreatic cancer: a multicenter retrospective observational comparative study on 217 patients,
35th Annual Meeting of European Society for Hyperthermic Oncology, 2023.09.26-28.

Latest publications of Oncothermia, mEHT:

Kleef R, Dank M, Herold M, Agoston EI, Lohinszky J, Martinek E, Herold Z, Szasz AM. (2023)
Comparison of the effectiveness of integrative immunomodulatory treatments and conventional therapies on the survival of selected gastrointestinal cancer patients.

Sci Rep. 2023 Nov 21;13(1):20360.

Fiorentini G, Sarti D, Mambrini A, Ferri IH, et.al. (2023)
Hyperthermia combined with chemotherapy vs chemotherapy in patients with advanced pancreatic cancer: A multicenter retrospective observational comparative study.

World J Clin Oncol. 2023 Jun 24;14(6):215-226.

Szász, A.M., Lóránt, G., Szász, A. and Szigeti, G. (2023)
The Immunogenic Connection of Thermal and Nonthermal Molecular Effects in Modulated Electro-Hyperthermia.

Open Journal of Biophysics , 13, 103-142.

Szasz, A. (2023)
Memristor Hypothesis in Malignant Charge Distribution.

Open Journal of Biophysics , 13, 51-92.

Dank M, Herold M, Garay TM, Gajdácsi J, Herold Z, Szász AM. (2023)
Electromagnetic procedures in the treatment of pancreatic cancer: eminent or resentful?

Magy Onkol 67:194–201, 2023


Insights from ESHO-ICHS Meeting

Advancements in Hyperthermia and Immunotherapy Intersection

We would like to thank those who participated in the latest event of ESHO-ICHS!

The conference of the European Society for Hyperthermic Oncology was held along with the ICHS – the Conference of International Clinical Hyperthermia Society – this year and took place in the city of Cologne in Germany from September 26 to 29.

The convergence of these two gatherings, both dedicated to advancing the application of hyperthermia in cancer treatment, provided a unique platform for interdisciplinary dialogue and became an exceptional opportunity for experts from diverse backgrounds to share knowledge and insights. In the field of mEHT, Dr. Carrie Minnaar, Prof Stefaan Van Gool, and Prof Giammaria Fiorentini also presented their promising research results, which we will soon publish in a collection of publications!

The meeting not only promoted the exchange of research but also recognized other existing directions of different hyperthermia methods, including the importance of the immuno-oncology approach. This development is particularly significant as it considers the ongoing efforts of Oncothermia, mEHT, and its synergistic potential of hyperthermia and immunotherapy in the fight against cancer.

The method of Oncothermia has been dealing with the possibilities inherent in immune effects for more than 15 years now and has already laid the foundation for this promising intersection of these fields with previous research and publications.

Our basic immune application is called “tumor vaccination” and was patented 10 years ago, recognizing firstly the immune effects of thermal and nonthermal combination in hyperthermia practice [[1]]. This immune effect was used in all abscopal (systemic extension of the local mEHT treatment [[2]]) studies [[3]], [[4]], [[5]], [[6]], [[7]], showing this effect in a Phase III clinical study, too [[8]], [[9]]. The immune effect is the consequence of the immunogenic cell death triggered mEHT [[10]], [[11]], [[12]], [[13]], and well observed in combination with radiotherapy [[14]], and in the complexity of stress-protein development [[15]]. Importantly, due to its special immunogenic effect, the mEHT method may be applicable in viral diseases (like COVID-19) as well [[16]], [[17]].

We are pleased to acknowledge the various conventional hyperthermia applications presented at the ESHO-ICHS meeting that have just begun to explore the combination of immunotherapies and thermal effects. The discussion about temperature homogeneity and the single fever range temperature of immune combination also shows that mEHT has been working at the forefront of hyperthermia research.

[2]    Szasz O. (2020)
Local treatment with systemic effect: Abscopal outcome, in book Challenges and solutions of oncological hyperthermia,
ed. Szasz A., Ch. 11, pp.192-205, Cambridge Scholars

[3]    Qin W, Akutsu Y, Andocs G, et al. (2014)
Modulated electro-hyperthermia enhances dendritic cell therapy through an abscopal effect in mice.
Oncol Rep 32(6):2373-2379,

[4]    Andocs G, Meggyeshazi N, Okamoto Y, Balogh L, Kovago Cs, Szasz O. (2013)
Oncothermia treatment induced immunogenic cancer cell death.
Oncothermia Journal 9:28-37,

[5]    Yoon S-M, Jung SL. (2012)
Case of Abscopal effect with Metastatic Non-Small-Cell Lung Cancer.
Oncothermia Journal 5:53-57,

[6]    Fiorentini G, Yoon SM, Yan O, Andocs G, Baronzio GF, Laurent S, Balogh L, Szasz A. (2013)
Abscopal effect: new perspectives in Oncothermia.
Oncothermia Journal 7:279-281,

[7]    Chi M-S, Mehta MP, Yang K-L, et al. (2020)
Putative abscopal effect in three patients treated by combined radiotherapy and modulated electrohyperthermia,
Frontiers in Oncology, 10:254, doi: 10.3389/fonc.2020.00254,

[9]    Minnaar CA, Kotzen JA, Ayeni OA, et al. (2020)
Potentiation of the abscopal effect by modulated electro-hyperthermia in locally advanced cervical cancer patients,
Frontiers in Oncology, 10(376):1-8,

[10]    Lee SY., Szasz A. (2022)
Immunogenic Effect of Modulated Electro-hyperthermia (mEHT) in Solid Tumors.
In: Interdisciplinary Cancer Research. Springer, Cham.

[11]    Van Gool S, Makalowski J, Feyen O. (2019)
Can we monitor immunogenic cell death (ICD) induced with modulated electrohyperthermia and oncolytivc virus injections?
Oncothermia Journal 26:120-125,

[12]    Szasz A. (2020)
Towards the immunogenic hyperthermic action: Modulated electro-hyperthermia,
Clinical Oncology and Research, Science Repository, 3(9):5-6,

[13]    Szasz AM, Lorant G, Szasz A, Szigeti Gy. (2023)
The immunogenic connection of thermal and nonthermal molecular effects in modulated electro-hyperthermia,
Open Journal of Biophysics, 13, 103-142,

[14]    Szasz A. (2022)
Heterogeneous heat absorption is complementary to radiotherapy,
Cancers, 14, 901,

[15]    Minnaar CA, Szasz A. (2022)
Forcing the antitumor effects of HSPs using a modulated electric field,
Cells, 11, 1838,

[16]    Masaud SM, Szasz O, Szasz AM, Ejaz H, Anwar RA, Szasz A. (2020)
A potential bioelectromagnetic method to slow down the progression  and prevent the development of ultimate pulmonary fibrosis by COVID-19,
Frontiers in Immunology, 11, 556335, doi: 10.3389/fimmu.2020.556335,

[[17]]    Szasz A. (2021)
A bioelectromagnetic proposal approaching the complex challenges of COVID-19,
Open Journal of Biophysics, 11, 1-67,


ICHS and ESHO 2023 event coming soon!

26-29 September 2023

Learn more about the event here!

The next ICHS conference will be held with the annual meeting of ESHO – the European Society for Hyperthermic Oncology!The two events will take place at the same time and place, from 26 to 29 September in Cologne, Germany!

As the object of both society is to promote the use of hyperthermia in cancer therapy, we believe that it is an excellent opportunity to exchange information between different disciplines in the study of the biological effects of heat in the treatment of cancer. The meeting could be the first step to unite all hyperthermia modalities, including oncothermia.

The registration is open now, don’t miss out!
Get your ticket now!

Take this great opportunity to meet colleagues and other experts, renew and establish new collaborations!

If you would like to learn more about ESHO 2023 click here!

We look forward to seeing you there!