Evaluation of single-arm studies of oncothermia
“Background: Oncothermia survival studies are problematic due to the missing control arm. This is a problem is general, when the treatment targets advanced, mostly refractory, relapsed malignancies in high treatment lines, when the only way is the sequential treatment. The sequential trial , , , is well known, and applied frequently in the case of small trials . The sequential trial (like the oncothermia) is applied for the same patient in sequences, In this approach the development of the patient is measured and documented.