Oncothermia is a highly personalized treatment modality. It is not a “gold standard” yet, but it is on the way to reach its position as a “fourth column” among the main oncotherapy modalities. It has wide-range applicability for every solid tumors in all possible localizations, irrespective its primary or metastatic form. It could be applied complementary to all the known oncotherapy methods. It is applicable in higher lines of the therapy protocols, even in the refractory and relapsed cases as well.