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10/25/2019 - 06:23 | Klinisch Wissenschaft Externe Nachrichten

Unser Anwender Prof. Giammaria Fiorentini hat einen Artikel zum Thema Oncothermie veröfentlicht

Please click here to the full version
Bauchspeicheldrüse im menschlichen Körper
Bauchspeicheldrüse im menschlichen Körper

Glückwunsch zu dieser hervorragenden Forschung!

Modulierte Elektro-Hyperthermie als Palliativbehandlung gegen Bauchspeicheldrüsenkrebs: eine retrospektive Beobachtungsstudie an 106 Patienten

Giammaria Fiorentini, MD1 , Donatella Sarti, PhD1, Virginia Casadei, MD1,
Carlo Milandri, MD2, Patrizia Dentico, MD2, Andrea Mambrini, MD3,
Roberto Nani, MD4, Caterina Fiorentini, MD5, and Stefano Guadagni, MD6

Abstract: Background: Pancreatic adenocarcinoma has a poor prognosis, resulting in a <10% survival rate at 5 years. Modulated electro-hyperthermia (mEHT) has been increasingly used for pancreatic cancer palliative care and therapy. Objective: To monitor the efficacy and safety of mEHT for the treatment of advanced pancreatic cancer. Methods: We collected data retrospectively on 106 patients affected by stage III-IV pancreatic adenocarcinoma. They were divided into 2 groups: patients who did not receive mEHT (no-mEHT) and patients who were treated with mEHT. We performed mEHT applying a power of 60 to 150 W for 40 to 90 minutes. The mEHT treatment was associated with chemotherapy and/or radiotherapy for 33 (84.6%) patients, whereas 6 (15.4%) patients received mEHT alone. The patients of the no-mEHT group received chemotherapy and/or radiotherapy in 55.2% of cases. Results: Median age of the sample was 65.3 years (range = 31-80 years). After 3 months of therapy, the mEHT group had partial response in 22/34 patients (64.7%), stable disease in 10/34 patients (29.4%), and progressive disease in 2/34 patients (8.3%). The no-mEHT group had partial response in 3/36 patients (8.3%), stable disease in 10/36 patients (27.8%), and progressive disease in 23/36 patients (34.3%). The median overall survival of the mEHT group was 18.0 months (range = 1.5-68.0 months) and 10.9 months (range = 0.4-55.4 months) for the non-mEHT group. Conclusions: mEHT may improve tumor response and survival of pancreatic cancer patients.