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Insights from ESHO-ICHS Meeting

Advancements in Hyperthermia and Immunotherapy Intersection

We would like to thank those who participated in the latest event of ESHO-ICHS!

The conference of the European Society for Hyperthermic Oncology was held along with the ICHS – the Conference of International Clinical Hyperthermia Society – this year and took place in the city of Cologne in Germany from September 26 to 29.

The convergence of these two gatherings, both dedicated to advancing the application of hyperthermia in cancer treatment, provided a unique platform for interdisciplinary dialogue and became an exceptional opportunity for experts from diverse backgrounds to share knowledge and insights. In the field of mEHT, Dr. Carrie Minnaar, Prof Stefaan Van Gool, and Prof Giammaria Fiorentini also presented their promising research results, which we will soon publish in a collection of publications!

The meeting not only promoted the exchange of research but also recognized other existing directions of different hyperthermia methods, including the importance of the immuno-oncology approach. This development is particularly significant as it considers the ongoing efforts of Oncothermia, mEHT, and its synergistic potential of hyperthermia and immunotherapy in the fight against cancer.

The method of Oncothermia has been dealing with the possibilities inherent in immune effects for more than 15 years now and has already laid the foundation for this promising intersection of these fields with previous research and publications.

Our basic immune application is called “tumor vaccination” and was patented 10 years ago, recognizing firstly the immune effects of thermal and nonthermal combination in hyperthermia practice [[1]]. This immune effect was used in all abscopal (systemic extension of the local mEHT treatment [[2]]) studies [[3]], [[4]], [[5]], [[6]], [[7]], showing this effect in a Phase III clinical study, too [[8]], [[9]]. The immune effect is the consequence of the immunogenic cell death triggered mEHT [[10]], [[11]], [[12]], [[13]], and well observed in combination with radiotherapy [[14]], and in the complexity of stress-protein development [[15]]. Importantly, due to its special immunogenic effect, the mEHT method may be applicable in viral diseases (like COVID-19) as well [[16]], [[17]].

We are pleased to acknowledge the various conventional hyperthermia applications presented at the ESHO-ICHS meeting that have just begun to explore the combination of immunotherapies and thermal effects. The discussion about temperature homogeneity and the single fever range temperature of immune combination also shows that mEHT has been working at the forefront of hyperthermia research.

[2]    Szasz O. (2020)
Local treatment with systemic effect: Abscopal outcome, in book Challenges and solutions of oncological hyperthermia,
ed. Szasz A., Ch. 11, pp.192-205, Cambridge Scholars

[3]    Qin W, Akutsu Y, Andocs G, et al. (2014)
Modulated electro-hyperthermia enhances dendritic cell therapy through an abscopal effect in mice.
Oncol Rep 32(6):2373-2379,

[4]    Andocs G, Meggyeshazi N, Okamoto Y, Balogh L, Kovago Cs, Szasz O. (2013)
Oncothermia treatment induced immunogenic cancer cell death.
Oncothermia Journal 9:28-37,

[5]    Yoon S-M, Jung SL. (2012)
Case of Abscopal effect with Metastatic Non-Small-Cell Lung Cancer.
Oncothermia Journal 5:53-57,

[6]    Fiorentini G, Yoon SM, Yan O, Andocs G, Baronzio GF, Laurent S, Balogh L, Szasz A. (2013)
Abscopal effect: new perspectives in Oncothermia.
Oncothermia Journal 7:279-281,

[7]    Chi M-S, Mehta MP, Yang K-L, et al. (2020)
Putative abscopal effect in three patients treated by combined radiotherapy and modulated electrohyperthermia,
Frontiers in Oncology, 10:254, doi: 10.3389/fonc.2020.00254,

[9]    Minnaar CA, Kotzen JA, Ayeni OA, et al. (2020)
Potentiation of the abscopal effect by modulated electro-hyperthermia in locally advanced cervical cancer patients,
Frontiers in Oncology, 10(376):1-8,

[10]    Lee SY., Szasz A. (2022)
Immunogenic Effect of Modulated Electro-hyperthermia (mEHT) in Solid Tumors.
In: Interdisciplinary Cancer Research. Springer, Cham.

[11]    Van Gool S, Makalowski J, Feyen O. (2019)
Can we monitor immunogenic cell death (ICD) induced with modulated electrohyperthermia and oncolytivc virus injections?
Oncothermia Journal 26:120-125,

[12]    Szasz A. (2020)
Towards the immunogenic hyperthermic action: Modulated electro-hyperthermia,
Clinical Oncology and Research, Science Repository, 3(9):5-6,

[13]    Szasz AM, Lorant G, Szasz A, Szigeti Gy. (2023)
The immunogenic connection of thermal and nonthermal molecular effects in modulated electro-hyperthermia,
Open Journal of Biophysics, 13, 103-142,

[14]    Szasz A. (2022)
Heterogeneous heat absorption is complementary to radiotherapy,
Cancers, 14, 901,

[15]    Minnaar CA, Szasz A. (2022)
Forcing the antitumor effects of HSPs using a modulated electric field,
Cells, 11, 1838,

[16]    Masaud SM, Szasz O, Szasz AM, Ejaz H, Anwar RA, Szasz A. (2020)
A potential bioelectromagnetic method to slow down the progression  and prevent the development of ultimate pulmonary fibrosis by COVID-19,
Frontiers in Immunology, 11, 556335, doi: 10.3389/fimmu.2020.556335,

[[17]]    Szasz A. (2021)
A bioelectromagnetic proposal approaching the complex challenges of COVID-19,
Open Journal of Biophysics, 11, 1-67,

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